Hyperthyroidism in Cats (Hyperthyrosis) 

Is your cat losing weight despite a good appetite? It might be suffering from hyperthyrosis. Our guide will tell you what you need to know about hyperthyroidism in cats. 

Cat being given daily thyroid medication for hyperthyroidism treatment

Cats with hyperthyroidism often need lifelong medication to manage their thyroid levels and maintain overall health

Symptoms: How does hyperthyroidism manifest in cats? 

The thyroid hormones affect important cell functions, so hyperthyroidism in cats impacts a variety of organs, leading to a variable clinical picture. 

Hyperthyroidism in cats often manifests in the following symptoms: 

  • High blood pressure 
  • Weight loss despite increased appetite 
  • Hair loss, and the remaining fur appears unkempt 
  • Cat panting and showing breathing difficulties 
  • Increased drinking and urination (polydipsia and polyuria) 
  • Increased activity and general agitation 
  • Difficulties with swallowing 

Sometimes you may also observe behavioural changes in your cat, such as sudden aggression or fear. If the illness affects the gastrointestinal tract, symptoms like diarrhoea or vomiting may occur. 

End-stage: What happens to untreated cats 

Without treatment, a cat with thyroid disease will gradually reach the end-stage of the illness. The hormones negatively affect the heart, causing blood pressure to rise. This elevated blood pressure then damages other organs such as the kidneys or eyes

Diagnosis: How is hyperthyroidism in cats detected? 

After an initial clinical examination, your vet can use various diagnostic tools to detect hyperthyroidism in cats: 

  • Blood tests: Once your vet has taken a blood sample from your cat, they can test it for various parameters. A hyperthyroidism in cats is often associated with an increase in liver enzymes (e.g. alanine aminotransferase or alkaline phosphatase). Due to the impaired muscle activity caused by hyperthyroidism, creatinine is often decreased
  • Thyroid tests: Your vet can also measure the concentration of different thyroid hormones in the blood, such as Serum-T4 or free T4 (ft4). The TSH test checks the communication between the pituitary gland in the brain and the thyroid gland. Your vet expects low TSH levels in sick cats because the elevated T4 suppresses TSH release from the pituitary gland. 
  • Ultrasound: Vets often use ultrasound to rule out thyroid disease. With the ultrasound device, they can evaluate the thyroid tissue for size, shape, and location. Meanwhile, they can also perform an ultrasound-guided fine-needle aspiration to take a tissue sample for assessment of a benign or malignant tumour. 
  • Scintigraphy: If your vet finds a nodule in the thyroid, they can use thyroid scintigraphy to check the thyroid’s iodine metabolism. Here, they administer radioactive substances (radionuclides) to your cat, which resemble iodine. The gamma radiation emitted by this radioactive substance can then be imaged by your vet using a special camera. The images are compared to the values of the salivary gland to detect changes in the thyroid
  • X-ray: Further diagnostic tools are also helpful to check the condition of other organs. For example, your vet can assess abdominal organs such as the liver or kidneys through an X-ray examination. 

Treatment: How is hyperthyroidism in cats treated? 

Veterinary medicine distinguishes between reversible and non-reversible treatments. 

1. Reversible treatment 

This treatment includes medicinal treatment with thyreostatics. Drugs like carbimazole, methimazole, or thiamazole inhibit the production of T4 and T3 hormones. If you stop methimazole medication, the thyroid begins to over-produce again.

Therefore, it’s a lifelong therapy. It’s also important to regularly check your cat’s thyroid levels (about every three months). Only then can your vet adjust the dosage individually and reduce side effects if possible. 

Additionally, or as an alternative to other treatments, you can change your cat’s diet. The exclusive feeding of iodine-reduced cat food regulates the concentration of elevated serum-T4. Your vet will inform you about which dietetic feeds are suitable for your cat. 

Note: Choosing an appropriate dietetic feed can support your cat’s natural bodily functions. Please note, however, that dietetic feed cannot cure or prevent diseases. You should always discuss your cat’s diet with your vet. You can find special dietetic feeds in the zooplus online shop. 

2. Non-reversible treatment 

Non-reversible measures are considered when reversible steps no longer work. The gold standard is radioiodine therapy. Here, radioactive labelled iodine injected into the veins or under the skin destroys the abnormally changed gland tissue. In most cases, one application is enough

A second possibility is thyroidectomy, which is the surgical removal of the entire thyroid gland

Hyperthyroidism in cats often manifests in different symptoms © nicholashan / stock.adobe.com
Hair loss and an unkempt coat may indicate hyperthyroidism in cats and should be assessed by a veterinarian.

How Expensive is the Treatment for Hyperthyroidism in Cats? 

The permanent medicinal therapy incurs ongoing costs. You can expect to spend about £35 on the necessary tablets. Additional costs for veterinary examinations will occur. The cost of surgical removal of the thyroid or radioiodine treatment varies between £3,000 and £4,000. However, factors such as the weight of your cat (for calculating the dose of necessary drugs) can individually influence the costs

Causes: What Triggers Hyperthyroidism in Cats? 

Hyperthyroidism (hyperthyrosis) occurs when your cat’s thyroid gland releases too many thyroid hormones. This important gland is located left and right of the trachea in your cat’s neck. The best-known thyroid hormones include thyroxine (T4) and triiodothyronine (T3). 

Tumour as the most common trigger 

Most commonly, pathological changes in the thyroid tissue are responsible for hyperthyroidism in cats. These include, for example, hormone-producing tumours of one or both thyroid lobes. The majority of cats with cancer have a benign adenoma. Less frequently, cats suffer from an aggressive T4-producing carcinoma. 

Other causes and contributing factors 

Some affected cats suffer from adenomatous hyperplasia. Here, the tissue of the thyroid gland multiplies, causing the gland to produce more hormones. Scientists have not yet fully clarified what leads to the development of hyperthyrosis in cats. The following factors, however, are suspected of potentially increasing the risk of disease: 

  • Radioactive radiation 
  • Chemical stimuli (e.g., toxins, antiparasitics) 
  • Cat litter 
  • Wet food with too high iodine concentrations 

Prognosis: Can hyperthyroidism in cats be cured? 

The prognosis for hyperthyroidism in cats is generally good. However, if your cat suffers from severe accompanying diseases (e.g. chronic kidney disease)), these can limit the life expectancy. If you do not treat your cat, it must be assumed that it will gradually reach the end-stage and lose life force. 

How Long Can a Cat With Hyperthyroidism Survive? 

Since most cats with hyperthyroidism have a benign thyroid tumour, these animals can look forward to a normal cat life without further restrictions after successful treatment. 

Prevention: Can You Protect Your Cat From Hyperthyroidism?

Unfortunately, you cannot prevent the hormonal disease. However, by following these tips, you can support your cat’s overall health: 

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